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YoDA-C: Youth Depression Alleviation: A Randomised Controlled Trial of Cognitive Behavioural Therapy with Fluoxetine or Placebo (YoDA-C)

Participants were aged 15-25 years with moderate to severe major depressive disorder. Participants were randomly assigned to receive cognitive behavioural therapy for 12 weeks, plus fluoxetine or placebo. Dataset includes demographic information, primary outcomes depression rating on the MADRS at baseline and 12 weeks, and other psychopathology information, including anxiety, substance use, suicidality, social and occupational functioning, quality of life, and satisfaction.

Subjects
Depression / Mental Health
Date made available
Data are available Immediately for an indefinite time.
Data set type
IPD
ANZCTR reference number
Publication
Davey CG, Chanen AM, Hetrick SE, Cotton SM, Ratheesh A, Amminger GP, Koutsogiannis J, Phelan M, Mullen E, Harrison BJ, Rice S, Parker AG, Dean OM, Weller A, Kerr M, Quinn AL, Catania L, Kazantzis N, McGorry PD, Berk M. The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial. Lancet Psychiatry. 2019 Sep;6(9):735-744. doi: 10.1016/S2215-0366(19)30215-9. Epub 2019 Jul 29. PMID: 31371212.
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