This 24-week double-blind, randomized, placebo controlled efficacy trial evaluated the efficacy of adjunctive mangosteen pericarp, compared to placebo, in the treatment of schizophrenia. People diagnosed with schizophrenia or schizoaffective disorder (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), recruited across 2 sites (Brisbane and Victoria, Australia), were randomized to receive 24 weeks of adjunctive mangosteen pericarp (1,000 mg/day) or matched placebo. The primary outcome measure was the Positive and Negative Symptom Scale total score. Secondary outcomes included positive and negative symptoms, general psychopathology, clinical global severity and improvement, participant reported overall improvement, depressive symptoms, functioning, quality of life, and safety data at 24 and 28 weeks (4 weeks post discontinuation). Data were collected from July 2016 to February 2019.
Subjects
Depression / Mental Health / Other mental health disorders
DOI Number
Date made available
All participant data will be available following the publication of the primary data. Data will be available following the publication of primary and secondary outcomes. No end date
Data set type
IPD
ANZCTR reference number
Publication
/
Dataset Access Link
Protocol
https://www.anzctr.org.au/Steps11and12/369695-(Uploaded-10-08-2023-14-23-04)-Study-related%20document.pdf